Interferons (IFNs) are a family of naturally existing glycoproteins known for their antiviral activity and their ability to influence\r\nthe behavior of normal and transformed cell types. Type I Interferons include IFN-?? and IFN-??. Currently, IFN-?? has numerous\r\napproved antitumor applications, includingmalignant melanoma, in which IFN-?? has been shown to increase relapse free survival.\r\nMoreover, IFN-?? has been successfully used in the intralesional treatment of cutaneous squamous cell carcinoma (SCC) and basal\r\ncell carcinoma (BCC). In spite of these promising clinical results; however, there exists a paucity of knowledge on the precise antitumor\r\naction of IFN-??/?? at the cellular and molecular levels in cutaneous malignancies such as SCC, BCC, and melanoma. This\r\nreview summarizes current knowledge on the extent to which Type I IFN influences proliferation, apoptosis, angiogenesis, and\r\nimmune function in normal skin, cutaneous SCC, BCC, and melanoma.
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